fiddle: a tool to combat publication bias by getting research out of the file drawer and into the scientific community

fiddle: a tool to combat publication bias by getting research out of the file drawer and into the scientific community

Statistically important findings usually tend to be revealed than non-significant or null findings, leaving scientists and healthcare personnel to make choices based mostly on distorted scientific proof. Repeatedly increasing ´file drawers’ of unpublished information from well-designed experiments waste assets creates issues for researchers, the scientific group and the general public. There may be restricted consciousness of the unfavourable impression that publication bias and selective reporting have on the scientific literature.

Various publication codecs have lately been launched that make it simpler to publish analysis that’s tough to publish in conventional peer reviewed journals. These embody micropublications, information repositories, information journals, preprints, publishing platforms, and journals specializing in null or impartial outcomes. Whereas these different codecs have the potential to scale back publication bias, many scientists are unaware that these codecs exist and do not know how one can use them.

Our open supply file drawer information liberation effort (fiddle) software is a match-making Shiny app designed to assist biomedical researchers to establish essentially the most applicable publication format for his or her information. Customers can seek for a publication format that meets their wants, evaluate and distinction totally different publication codecs, and discover hyperlinks to publishing platforms. This software will help scientists in getting in any other case inaccessible, hidden information out of the file drawer into the scientific group and literature.

Pitfalls in scientific analysis: vital appraisal of articles revealed in one of many worldwide journals in Egypt

To establish and report flaws of Web-published articles within the Journal of the Egyptian Nationwide Most cancers Institute (JENCI), Cairo College, by means of a retrospective documentary research on articles revealed through the interval from 2011 to 2016. All sections have been reviewed in opposition to a collective guidelines. Articles have been grouped by publication yr into 2 intervals: early (from 2011 to 2013) and up to date (from 2014 to 2016) to establish adjustments in research traits over time. The research included 139 unique articles. Half of the titles represented purpose and 9.4% represented research design.
Abstracts have been concise, clear, with structured writing format in 98.6%, 93.5%, and 35.3%, respectively. Most introductions included the research purpose, whereas 41% had a rationale. Examine timing was reported in 59.0%, whereas the research design was reported in 25.9%. Inclusion and exclusion standards have been clearly reported in 43.1% and 40.1%, respectively. Statistical strategies have been talked about in 80.6%, full in 30.4%, and applicable in 85.7%. We briefly spotlight important particulars that ought to be included to make sure reporting high quality, which is able to enable others to make use of and profit from analysis revealed in these new codecs.
4 research reported pattern measurement estimation. Solely 52.5% and 58.3% of outcomes have been exhaustive and reply the analysis query, respectively. Incorrect statistical calculations occurred in 41.0%, inappropriate statistical checks or descriptive parameter choice in 26.6%, whereas inappropriate take a look at software occurred in 49.1%. About 60% of discussions didn’t fully cowl outcomes, 31.7% totally justified the findings, 56.1% adopted a logical circulate, and 36.7% had contradiction inside the textual content. Conclusions have been principally linked to purpose, imprecise, and extrapolating past outcomes.
On evaluating each intervals, solely a major much less misuse of statistical phrases, extra reporting battle of curiosity, extra lacking references for cited texts within the current interval, and extra participation of NCI over different institutes within the early interval have been discovered. Articles revealed in JENCI (from 2011 to 2016) had many methodological and reporting defects and a few factors of energy. Utilizing the collective guidelines developed by this research, steady coaching of researchers, involving epidemiologists all through the entire analysis course of, and making use of strict journal reporting and publication guidelines ought to be inspired.
fiddle: a tool to combat publication bias by getting research out of the file drawer and into the scientific community

A complete bibliometrics of ‘walkability’ analysis panorama: visualization of the scientific progress and future prospects

This research quantitatively investigated the scientific progress of walkability analysis panorama and its future prospects utilizing bibliometric indicators to spotlight the analysis hotspots. The outcomes accentuated multifaceted nature of walkability analysis panorama with a robust affiliation in direction of public well being disciplines. Key phrase co-occurrence evaluation emphasised that majority of the walkability research centred on the interactions between strolling and different three predominant elements resembling constructed atmosphere attributes, transportation and weight problems.

Plasmid ezFilter Midi Kit II, Centrifuge

K1317-25
EUR 446

Plasmid ezFilter Midi Kit I, Centrifuge

K1316-10
EUR 343

Plasmid ezFilter Midi Kit I, Centrifuge

K1316-2
EUR 262

Plasmid ezFilter Midi Kit I, Centrifuge

K1316-25
EUR 425

ToxOut? Endofree ezFilter Plasmid Midi Kit

K1329-10
EUR 316

ToxOut? Endofree ezFilter Plasmid Midi Kit

K1329-2
EUR 207

ToxOut? Endofree ezFilter Plasmid Midi Kit

K1329-25
EUR 533

Plasmid Midi Kit II

K1315-10
EUR 370

Plasmid Midi Kit II

K1315-2
EUR 262

Plasmid Midi Kit II

K1315-25
EUR 425

BlotBot Midi Blot Tray

TRAY-MIDI-2 2pack
EUR 202
Description: Replacement tray for the BlotBot allows you to run 1 Midi sized blot. Pack of 2 trays.

Plasmid ezFilter Maxi Kit

K1319-10
EUR 392

Plasmid ezFilter Maxi Kit

K1319-25
EUR 610

Plasmid ezFilter Mega3 Kit

K1320-1
EUR 262

Plasmid ezFilter Mega3 Kit

K1320-10
EUR 887

Plasmid ezFilter Mega3 Kit

K1320-2
EUR 343

Plasmid ezFilter Mega6 Kit

K1321-1
EUR 283

Plasmid ezFilter Mega6 Kit

K1321-10
EUR 968

Plasmid ezFilter Mega6 Kit

K1321-2
EUR 370

Plasmid ezFilter Mega10 Kit

K1322-1
EUR 343

Plasmid ezFilter Mega10 Kit

K1322-10
EUR 1104

Plasmid ezFilter Mega10 Kit

K1322-2
EUR 452

Plasmid Midi Kit I

K1314-10
EUR 332

Plasmid Midi Kit I

K1314-2
EUR 262

Plasmid Midi Kit I

K1314-25
EUR 392

Fast Ion Plasmid Midi Kit

FYG002-25P 25 Preps Ask for price

ToxOut? Endofree Plasmid Midi Kit

K1328-10
EUR 316

ToxOut? Endofree Plasmid Midi Kit

K1328-2
EUR 207

ToxOut? Endofree Plasmid Midi Kit

K1328-25
EUR 479

96-well Plasmid ezFilter Mini Kit

K1325-96-1
EUR 370

96-well Plasmid ezFilter Mini Kit

K1325-96-4
EUR 968

ToxOut? Endofree ezfilter Plasmid Maxi Kit

K1331-10
EUR 425

ToxOut? Endofree ezfilter Plasmid Maxi Kit

K1331-2
EUR 234

ToxOut? Endofree ezfilter Plasmid Maxi Kit

K1331-25
EUR 642

Human Kinase Library II

HKIN-II 1 set
EUR 450

Human Drug Detoxication II

HDTX-II 1 set
EUR 645

Human Cytokine Primer Library II

HCA-II 1 set
EUR 450

Mouse Cytokine Primer Library II

MCA-II 1 set
EUR 450

Rat Cytokine Primer Library II

RCA-II 1 set
EUR 548

ToxOut? Express Endofree Plasmid Midi Kit

K1335-10
EUR 370

ToxOut? Express Endofree Plasmid Midi Kit

K1335-2
EUR 234

ToxOut? Express Endofree Plasmid Midi Kit

K1335-25
EUR 697

T-Pro Plasmid Midi Kit (20)

RB94-YPI020 20preps/Kit
EUR 213

Human Colon Cancer Primer Library II

HCCP-II 1 set
EUR 548

Human DNA Repair Primer Library II

HDRL-II 1 set
EUR 548

Mouse DNA Repair Primer Library II

MDRL-II 1 set
EUR 645

Human Interferon Type II Signaling Primer Library

HIFN-II 1 set
EUR 548

Human Cancer Driver Gene II Primer Library

HCDG-II 1 set
EUR 645

Fast Ion Plasmid Midi KitEndotoxin Free

FYG003-25P 25 Preps Ask for price

Plasmid DNA Extraction Midi Kit (25prep), Ion Exchange

FAPDE-002 25 preps
EUR 216

Plasmid DNA Extraction Midi Kit (50prep), Ion Exchange

FAPDE-002-1 50 preps
EUR 317

High Speed Plasmid Midi Kit (25prep), Ion Exchange

FAPDE-002-SP2 25 preps
EUR 361

FavorFilter Plasmid Midi SP Kit (25prep)-spin column

FAPDE-005-M-025 25 preps
EUR 150

FavorFilter Plasmid Midi SP Kit (50prep)-spin column

FAPDE-005-M-050 50 preps
EUR 187

T-Pro Endotoxin Removal Plasmid Midi kit (25)

RB94-EPI020 20preps/Kit
EUR 248

CMV-hspCas9-T2A-Puro SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit

CASLV100PA-KIT 1 Kit
EUR 1132
  • Category: Cas9

CMV-hspCas9-EF1-GFP SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit

CASLV105PA-KIT 1 Kit
EUR 1132
  • Category: Cas9

MSCV-hspCas9-T2A-Puro SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit

CASLV120PA-KIT 1 Kit
EUR 1132
  • Category: Cas9

MSCV-hspCas9-EF1-GFP SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit

CASLV125PA-KIT 1 Kit
EUR 1132
  • Category: Cas9

Plasmid DNA Extraction Midi Kit (25prep), FavorFilter, Ion Exchange

FAFTE-002 25 preps
EUR 245

Plasmid DNA Extraction Midi Kit (50prep), FavorFilter, Ion Exchange

FAFTE-002-1 50 preps
EUR 368

Plasmid DNA Extraction Midi Kit (25prep), EndoToxinFree, Ion Exchange

FAPDE-002-EF 25 preps
EUR 230

Plasmid DNA Midi Endotoxin Removal kit(25prep)-spin column

FAPDE-005B-025 25 preps
EUR 165

Plasmid DNA Midi Endotoxin Removal kit(50prep)-spin column

FAPDE-005B-050 50 preps
EUR 227

Cas9 Nickase: CMV-hspCas9(D10A)-T2A-Puro SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit

CASLV200PA-KIT 1 Kit
EUR 1132
  • Category: Cas9

Cas9 Nickase: CMV-hspCas9(D10A)-EF1-GFP SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit

CASLV205PA-KIT 1 Kit
EUR 1132
  • Category: Cas9

Cas9 Nickase: MSCV-hspCas9(D10A)-T2A-Puro SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit

CASLV220PA-KIT 1 Kit
EUR 1132
  • Category: Cas9

Cas9 Nickase: MSCV-hspCas9(D10A)-EF1-GFP SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit

CASLV225PA-KIT 1 Kit
EUR 1132
  • Category: Cas9

Plasmid Miniprep Kit II

K1313-250
EUR 370

Plasmid Miniprep Kit II

K1313-50
EUR 283

Soil DNA Isolation Midi Kit (24prep)

FASOI-002 24 preps
EUR 216

ISOLATE II Plasmid Mini Kit

BIO-52055 10 preps Ask for price

ISOLATE II Plasmid Mini Kit

BIO-52056 50 preps Ask for price

ISOLATE II Plasmid Mini Kit

BIO-52057 250 preps Ask for price

pCold II Plasmid

PVT0602 2 ug
EUR 301

Frit Kit

FRIT-KIT 1each
EUR 124
Description: Kit to create frits in capillaries. Includes formamide, Kasil-1, Kasil-1624 and a cleaving tool.

T-Pro Genomic DNA Midi Kit (20)

RB94-NGM020 20preps/kit
EUR 222

Column Packing Kit

PACK-KIT 1pack
EUR 1035
Description: Column packing kit for pressure cells. Includes: HPREG regulator, TBNG10 tubing, CAP-75 capillary, and STRB5X2 stir bar.

RapidSeq High Yield Directional mRNA Sample Prep Kit - With Aligner 13-24

KS073012-II 1 Kit
EUR 1142
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

RapidSeq High Yield Small RNA Sample Prep Kit - With Aligner 13-24

KS074012-II 1 Kit
EUR 1021
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

Attoglow Western Blot Analysis Kit- with Millennium Enhancer, Anti rabbit secondary antibody

K3171120-II 1200 cm2
EUR 246
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Attoglow Western Blot Analysis Kit- with Millennium Enhancer, Anti rabbit secondary antibody

K3171250-II 2500 cm2
EUR 310
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

midi horizontal unit 15x15 cm

EHS3400-SYS ea
EUR 631

midi horizontal unit 15x25 cm

EHS3410-SYS ea
EUR 775

midi horizontal unit 20x25 cm

EHS3500-SYS ea
EUR 817

midi horizontal unit 10x7 cm

EHS1201-SYS ea
EUR 352

midi horizontal unit 10x10 cm

EHS1202-SYS ea
EUR 352

midi gel dryer 21x31 cm

EDRY1100 ea
EUR 1873

PCR Mycoplasma Detection Kit

M034-Kit Kit
EUR 266

ToxOut? Endofree Plasmid Mini Kit II

K1327-250
EUR 697

ToxOut? Endofree Plasmid Mini Kit II

K1327-50
EUR 272

Holder for Plasmid Midi, Maxi and Maxi plus, Ion Exchange column

FAPDE-holder-for-ion-exchange 1 prep
EUR 158

pBluescript II SK+ Plasmid

PVT0011 2 ug
EUR 301

pBluescript II KS+ Plasmid

PVT0012 2 ug
EUR 301

T-Pro Plant Genomic DNA Midi Kit (20)

RB94-PGM020 20preps/kit
EUR 222

Cas9 Protein and T7 gRNA SmartNuclease Synthesis Kit

CAS400A-KIT 1 kit (10 rxn)
EUR 1110
  • Category: Cas9

Multiplex gRNA Kit + EF1-T7-hspCas9-H1-gRNA linearized SmartNuclease vector

CAS700A-KIT 10 rxn
EUR 1132
  • Category: Cas9

Multiplex gRNA Kit + CAG-T7-hspCas9-H1-gRNA linearized SmartNuclease vector

CAS720A-KIT 10 rxn
EUR 1132
  • Category: Cas9

Multiplex gRNA Kit + CMV-T7-hspCas9-H1-gRNA linearized SmartNuclease vector

CAS740A-KIT 10 rxn
EUR 1132
  • Category: Cas9

ICE PAN, RECTANGULAR, MIDI, 4L, GREEN

432103 1/pk
EUR 131
Description: BioCision; BioCision TruCool

ICE PAN, RECTANGULAR, MIDI, 4L, BLUE

432104 1/pk
EUR 131
Description: BioCision; BioCision TruCool

ICE PAN, RECTANGULAR, MIDI, 4L, RED

432105 1/pk
EUR 131
Description: BioCision; BioCision TruCool

ICE PAN, RECTANGULAR, MIDI, 4L, ORANGE

432106 1/pk
EUR 131
Description: BioCision; BioCision TruCool

ICE PAN, RECTANGULAR, MIDI, 4L, PINK

432108 1/pk
EUR 131
Description: BioCision; BioCision TruCool

ICE PAN, RECTANGULAR, MIDI, 4L, PURPLE

432109 1/pk
EUR 131
Description: BioCision; BioCision TruCool

midi horizontal unit 10x7 & 10x10 cm

EHS1200-SYS ea
EUR 378

supporting mask for midi gel dryer

EDRY1100-MASK ea
EUR 301

ssilicone rubber for midi gel dryer

EDRY1100-SILRUB ea
EUR 90

semi dry blotter midi 20x20 cm

ESDB1200 ea
EUR 1113

semi dry blotter midi 20x20 cm

ESDB3200 ea
EUR 1239

T7 gRNA SmartNuclease Synthesis Kit (includes CAS510A-1 & T7 IVT synthesis reagents)

CAS510A-KIT 1 Kit
EUR 805
  • Category: Cas9

Multiplex gRNA Kit + Cas9 Nickase: EF1-T7-hspCas9-nickase-H1-gRNA linearized SmartNickase vector

CAS750A-KIT 10 rxn
EUR 1132
  • Category: Cas9

Multiplex gRNA Kit + Cas9 Nickase: CAG-T7-hspCas9-nickase-H1-gRNA linearized SmartNickase vector

CAS770A-KIT 10 rxn
EUR 1132
  • Category: Cas9

Multiplex gRNA Kit + Cas9 Nickase: CMV-T7-hspCas9-nickase-H1-gRNA linearized SmartNickase vector

CAS790A-KIT 10 rxn
EUR 1132
  • Category: Cas9

Cas9 SmartNuclease Extra Ligation Kit [includes 5x ligation buffer (10 ul) and Fast ligase (2.5ul)]

CAS9LIG-KIT 1 Kit
EUR 153
  • Category: Cas9

PinPoint-FC 293T Platform Kit for Targeted Gene Insertion (includes PIN320A-1, PIN200A-1, PIN510A-1 & PIN600A-1)

PIN320A-KIT 1 Kit
EUR 4941
  • Category: PinPoint Integrase Tools

PinPoint-FC Murine iPSC Platform Kit for Targeted Gene Insertion (includes PIN340iPS-1, PIN200A-1, PIN510A-1 & PIN600A-1)

PIN340iPS-KIT 1 Kit
EUR 4941
  • Category: PinPoint Integrase Tools

pGreen II 62-SK Plasmid

PVT3026 2 ug
EUR 356

pBluescript II SK-DCLK1 Plasmid

PVTB00129S 2 ug
EUR 356

Aligner 13-24

KS072012-II 1 Kit
EUR 412
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

ICE PAN, RECTANGULAR, MIDI, 4L, LIME GREEN

432107 1/pk
EUR 131
Description: BioCision; BioCision TruCool

AAVS1 Safe Harbor Targeting Vector 2.0 - All-Purpose Donor (AAVS1-SA-puro-MCS), Complete Kit with CAS601A-1 (Cas9 SmartNuclease AAVS1-gRNA Targeting Vector) and GE640PR-1 (Junction PCR Primer Mix to confirm AAVS1 integration site)

GE620A-KIT 1 kit
EUR 2132
  • Category: Gene Editing

AAVS1 Safe Harbor Targeting Vector 2.0 - GOI Knock-in Donor (AAVS1-SA-puro-EF1-MCS), Complete Kit with CAS601A-1 (Cas9 SmartNuclease AAVS1-gRNA Targeting Vector) and GE640PR-1 (Junction PCR Primer Mix to confirm AAVS1 integration site)

GE622A-KIT 1 kit
EUR 2132
  • Category: Gene Editing

Primarily based on the recognized analysis hotspots, a quick state-of-the-art overview of walkability research was offered. Future prospects based mostly on the unexplored analysis gaps inside the hotspots have been additionally mentioned. Excessive correlation (r = 0.99, p < 0.05) between annual publications and quotation counts demonstrated the importance of walkability research to the modern scientific group. Being one of many complete research to guage the historic trajectory of walkability analysis panorama, the findings have been anticipated to speed up a complete understanding of the walkability analysis area that can help future analysis route.