NIH Funding, Research Productivity, and Scientific Impact: a 20-Year Study

NIH Funding, Research Productivity, and Scientific Impact: a 20-Year Study

The paper addresses the problems of admissibility of human embryo analysis and the authorized safety to be acknowledged, in gentle of the rising significance that scientific analysis has been gaining within the medical and biomedical fields of embryonic stem cells for therapeutic functions. As for human embryo experimentation, notably on cryopreserved supernumerary embryos, European laws varies, for the reason that European Court docket has granted member States a large margin of appreciation.

Some nations, together with Italy, have strict laws defending embryos from the fertilisation stage, whereas others have taken permissive approaches, permitting experimentation till 14 days after fertilisation. Science, nevertheless, has proven that the 14-day restrict may be moved. The creator finds it mandatory to realize broad worldwide consensus and shared laws. Lawmakers, nevertheless, must stability respect for the precept of life, represented by the embryo, towards scientific wants, in an effort to devise sound laws safeguarding each apparently conflicting basic values.

The Analysis Challenge Grant (R01) is the oldest grant mechanism utilized by the Nationwide Institutes of Well being (NIH). Receiving an R01 award is usually taken as an indication of scientific success. We introduced normative information on a number of productiveness and impression metrics for a extra goal evaluation of funded grants’ scientific success.  All preliminary R01 grants awarded by NIH within the 12 months 2000 had been prospectively adopted and evaluated utilizing the numbers of publications and citations, in addition to the h-indices on the grant degree. We examined the variability, time traits, and relations amongst these metrics to raised perceive the funded tasks’ cumulative output and impression.

Introducing Key Components Relating to Entry to Private Information for Scientific Analysis within the Perspective of Growing Revolutionary Medicines

This text goals at opening discussions and selling future analysis about key components that must be taken under consideration when contemplating new methods to organise entry to non-public information for scientific analysis within the perspective of creating revolutionary medicines. It supplies an summary of those key components: the alternative ways of accessing information, the speculation of the important services, the Regulation on the Free Move of Non-personal Information, the Directive on Open Information and the re-use of public sector data, and the Basic Information Safety Regulation (GDPR) guidelines on accessing private information for scientific analysis.

Within the perspective of fostering analysis, selling revolutionary medicines, and having all of the uncooked information centralised in huge databases localised in Europe, we advise to additional examine the likelihood to search out acceptable and balanced options with full respect of basic rights, in addition to for personal life and information safety. These embrace utilizing open science platforms, pre-registering research, making certain reproducible analyses, utilizing high-powered research, making certain open entry to analysis supplies and merchandise, and conducting replication research.

Suicide analysis is vitally vital, yet-like psychology analysis extra broadly-faces methodological challenges. In recent times, researchers have raised considerations about customary practices in psychological analysis, considerations that apply to suicide analysis and lift questions on its robustness and validity. Within the current paper, we evaluate these considerations and the corresponding options put forth by the “open science” neighborhood.

We construct upon current guides, deal with particular obstacles confronted by suicide researchers, and supply a transparent set of beneficial practices for suicide researchers. Specifically, we contemplate challenges that suicide researchers could face in searching for to undertake “open science” practices (e.g., prioritizing massive samples) and recommend attainable methods that the sector could use in an effort to guarantee strong and clear analysis, regardless of these challenges.

NIH Funding, Research Productivity, and Scientific Impact: a 20-Year Study

Enhancing open and rigorous science: ten key future analysis alternatives associated to rigor, reproducibility, and transparency in scientific analysis

As a part of a coordinated effort to broaden analysis exercise round rigor, reproducibility, and transparency (RRT) throughout scientific disciplines, a crew of investigators on the Indiana College Faculty of Public Well being-Bloomington hosted a workshop in October 2019 with worldwide leaders to debate key alternatives for RRT analysis.

The workshop aimed to establish analysis priorities and alternatives associated to RRT.  Over two-days, workshop attendees gave displays and took part in three working teams: (1) Enhancing Training & Coaching in RRT, (2) Lowering Statistical Errors and Rising Analytic Transparency, and (3) Wanting Outward: Rising Truthfulness and Accuracy of Analysis Communications. Following small-group discussions, the working teams introduced their findings, and contributors mentioned the analysis alternatives recognized. The investigators compiled an inventory of analysis priorities, which had been circulated to all contributors for suggestions.

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Members recognized the next precedence analysis questions: (1) Can RRT-focused statistics and mathematical modeling programs enhance statistics apply?; (2) Can specialised coaching in scientific writing enhance transparency?; (3) Does modality (e.g. nose to nose, on-line) have an effect on the efficacy RRT-related schooling?; (4) How can automated packages assist establish errors extra effectively?; 

What’s the prevalence and impression of errors in scientific publications (e.g., analytic inconsistencies, statistical errors, and different goal errors)?; (6) Do error prevention workflows cut back errors?; (7) How can we encourage post-publication error correction?; (8) How does ‘spin’ in analysis communication have an effect on stakeholder understanding and use of analysis proof?; (9) Do instruments to assist writing analysis studies enhance comprehensiveness and readability of analysis studies?; and (10) Is it attainable to inculcate scientific values and norms associated to truthful, rigorous, correct, and complete scientific reporting? Members recognized vital and comparatively unexplored questions associated to bettering RRT. This record could also be helpful to the scientific neighborhood and investigators searching for to advance meta-science (i.e. analysis on analysis).

Scientific HIV research in Africa and the Middle East: a socio-economic demographic analysis

Scientific HIV research in Africa and the Middle East: a socio-economic demographic analysis

Background: In Africa, HIV/AIDS analysis is concentrated in sure nations, notably South Africa. This distribution might not precisely replicate the illness prevalence or the true analysis efforts of nations. Aims: To establish HIV/AIDS analysis productiveness of nations in Africa and the Center East, in absolute phrases and adjusted for individuals dwelling with HIV, inhabitants dimension and financial growth. Strategies: We recognized all of the articles and opinions on HIV and AIDS within the Internet of Science Core Assortment through which African or Center Jap nations had participated. After figuring out the variety of paperwork produced by every nation, we adjusted the findings for the variety of individuals dwelling with HIV, variety of inhabitants, gross home product and gross nationwide revenue per capita. 

 African and Center Jap nations participated in 21.52% (n = 14 808) of all 68 808 paperwork analysed. East and Southern Africa produced 17.8% of all paperwork (n = 12 249), West and Central Africa accounted for under 3.34% (n = 2300), and the Center East and North Africa, 1.18% (n = 814). South Africa produced 40.94% (n = 6 063) of all publications. Solely two different African nations – Uganda (12.97%; n = 1 921) and Kenya (10.71%; n = 1 586) – produced greater than 10% of those publications. The indices used for adjusting analysis productiveness revealed the hassle and contribution of different nations. Conclusion: Our examine confirmed the main function of South Africa in driving HIV/AIDS analysis, but additionally highlighted the contribution of nations corresponding to Uganda, Malawi, Botswana, Zimbabwe and Mozambique.

In complete, 75 articles have been chosen. There was a rise within the variety of SRs on CBCT from 2014 onwards, as 83% of the SRs on this matter have been printed after 2013, and 72% between 2016 and up to now. Twenty SRs (27%) carried out meta-analysis. Solely 28% of the SRs supplied an in depth description of CBCT protocols. In response to SR proof, virtually all specialties of dentistry have superior concomitantly with the introduction of CBCT. Nearly all of SRs have been associated to medical purposes (degree 2 of efficacy), adopted by technical parameters (degree 1 of efficacy).

Just some CBCT fashions have been talked about within the SRs chosen. Over the course of twenty years, SRs associated to CBCT purposes for a broad vary of dental specialties have been printed, with the overwhelming majority of research at ranges 1 and a pair of of diagnostic efficacy. Not all fashions accessible in the marketplace have been scientifically validated. Always, one ought to stay cautious as such to not merely extrapolate in vitro outcomes to the medical setting. Additionally, contemplating the big variety of CBCT gadgets and protocols, reported outcomes shouldn’t be overstated or generalized, as outcomes typically confer with particular CBCT gadgets and protocols.

Bibliometric Evaluation of International Scientific Analysis on COVID-19

For the reason that outbreak of coronavirus illness 2019 (COVID-19), a lot of COVID-19-related studies have been printed in journals or submitted to preprint platforms. On this examine, we search the COVID-19-related literature formally printed and included within the Internet of Science (WOS) database or submitted to 4 preprint platforms: bioRxiv, medRxiv, Preprints, and SSRN. Utilizing knowledge on the variety of studies, creator establishment, nation, and analysis class, we analyze international tendencies in COVID-19 analysis, together with establishment distribution and analysis hotspots. The outcomes present that a lot of COVID-19-related studies have been produced; america has contributed probably the most printed literature, adopted by China.

America has additionally printed probably the most studies included within the WOS within the classes of non-pharmaceutical interventions, therapy, and vaccine-related studies, whereas China has printed probably the most literature within the classes of medical options and issues, virology and immunology, epidemiology, and detection and prognosis. Publication nations are concentrated in Asia, North America, and Europe, whereas South America and Africa have much less literature. In conclusion, many scientific analysis points associated to COVID-19 should be additional clarified and COVID-19 analysis urgently wants international cooperation.

Scientific HIV research in Africa and the Middle East: a socio-economic demographic analysis

Standardized Definitions for Analysis of Coronary heart Failure Therapies: Scientific Professional Panel From the Coronary heart Failure Collaboratory and Tutorial Analysis Consortium

The Coronary heart Failure Tutorial Analysis Consortium is a partnership between the Coronary heart Failure Collaboratory (HFC) and Tutorial Analysis Consortium (ARC), comprised of main coronary heart failure (HF) educational analysis investigators, sufferers, United States (US) Meals and Drug Administration representatives, and trade members from the US and Europe. A collection of conferences have been convened to ascertain definitions and key ideas for the analysis of HF therapies together with optimum medical and machine background remedy, medical trial design parts and statistical ideas, and examine endpoints.

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This manuscript summarizes the professional panel discussions as consensus suggestions centered on populations and endpoint definitions; it isn’t exhaustive or restrictive, however designed to stimulate HF medical trial innovation. Murray Sidman’s (1960) Ways of Scientific Analysis: Evaluating Experimental Information in Psychology simply celebrated its sixtieth anniversary. It’s doubtless one of the vital influential books within the historical past of Conduct Evaluation. This evaluation outlines the rationales for, and particulars of, strategies for the investigation of the habits of particular person topics that Sidman offered. Lots of his observations and proposals are as well timed as ever, perhaps much more so, given the “reproducibility disaster” and certainly one of its main origins.

Reporting consciousness in coma: media framing of neuro-scientific research, hope, and the response of families with relatives in vegetative and minimally conscious states

Reporting consciousness in coma: media framing of neuro-scientific research, hope, and the response of families with relatives in vegetative and minimally conscious states

This paper examines the general public illustration of, and household responses to, scientific research into consciousness in coma-like states. We look at the publicity surrounding high-profile research utilizing purposeful Magnetic Resonance Imaging (fMRI) on ‘vegetative’ or ‘minimally aware’ sufferers and evaluate this with household views. Our findings present how, with a couple of notable exceptions, the analysis was offered as a tremendous breakthrough providing a possible ‘voice’ and selection for sufferers and hope and luxury for his or her households. We argue that such representations ignored key limitations, evoked unrealistic visions of restoration, and promoted very slim representations of household reactions.

The comparability between public representations of the science and responses from households with expertise of this situation highlights the complicated social/medical world into which neurotechnologies intervene, and factors to the absence of a variety of affected person/household views in public discourse. We conclude with recommendations for the way these selling the analysis, and the journalists reporting its implications, may act to make sure extra accountable protection and improve public debate.

First, we affirm earlier analysis in suggesting that e-cigarettes appeared to have triggered a breakdown of outdated public well being alliances. Second, we display that, amid issues about analysis high quality and amount, actors are guided by normative outlooks (and/or financial pursuits) of their assessments of proof. Third, we present that, regardless of describing e-cigarette debates as contentious and polarised, actors partaking in Scottish coverage debates exhibit a spectrum of views, with most interviewees occupying an unsure ‘center floor’ that’s attentive to new proof.

Fourth, we propose that the perceived divisiveness of e-cigarette debates is attributed to recurrent media simplifications and tensions arising from the behaviours of some actors with settled positions working to advertise explicit coverage responses (together with by strategically enrolling supportive proof). Fifth, we argue that the actions of those actors are doubtlessly defined by the prospect that e-cigarettes may usher in a brand new tobacco ‘coverage paradigm’. Lastly, we present how scientific authority is employed as a device inside these debates.

Chemosensory Programs in COVID-19: Evolution of Scientific Analysis

COVID-19 illness induced by coronavirus SARS-CoV-2 presents amongst its signs alterations of the chemosensory capabilities. Within the first research on the Chinese language inhabitants, this symptomatology was not notably related, and hyposmia and hypogeusia have been excluded from the signs to be evaluated to diagnose the illness. With the pandemic unfold of the sickness, there was an increase in reviews on chemosensory dysfunctions amongst sufferers. The primary information evaluation confirmed the presence of those problems primarily in paucisymptomatic and asymptomatic sufferers. The curiosity in chemosensory techniques due to this fact elevated significantly, as a result of the olfactory and gustatory signs could possibly be the important thing to cease the an infection unfold.
Moreover, the diploma of alert and a focus grew, contemplating that these kind of dysfunctions are prognostic signs of significant neurodegenerative illnesses. About 9 months have handed because the first anecdotal reviews on the involvement of the olfactory and gustatory techniques within the COVID-19 pathology. Because of this, a cautious evaluation of the literature was performed to grasp whether it is clearer which individuals current chemosensory signs and if these are associated to the severity of the illness. Moreover, we have now recognized which facets nonetheless stay to be clarified. This novel consequence may be defined with self-determination of students as an important determinant supporting scientific manufacturing that outclasses shrinking public analysis lab budgets and organizational deficiencies.
Throughout the early levels of the pandemic, analysis performed on hydroxychloroquine (HCQ) was chaotic and sparked a number of heated debates with respect to the scientific strategies used and the standard of data generated. Analysis on HCQ is used as a case research in each papers. The authors explored biomedical databases, peer-reviewed journals, pre-print servers, and media articles to establish related literature on HCQ and COVID-19, and examined philosophical views on medical analysis within the context of this pandemic and former world well being challenges.
Reporting consciousness in coma: media framing of neuro-scientific research, hope, and the response of families with relatives in vegetative and minimally conscious states

How self-determination of students outclasses shrinking public analysis lab budgets, supporting scientific manufacturing: a case research and R&D administration implications

The principle objective of this research is to research how reorganization of public analysis organizations and shrinking public analysis lab budgets have an effect on the evolution of analysis exercise and scientific productiveness. This research focuses on a case research of Nationwide Analysis Council of Italy (CNR), one among largest European public analysis organizations, to establish evolution of analysis actions and dynamics of scientific manufacturing from 2000 to 2019. The statistical evaluation means that, consistent with the origin of the CNR, scientific analysis focuses primarily on analysis fields of pure sciences, comparable to chemical, life and bodily sciences, with an growing position of scientific analysis in power, engineering and arithmetic.

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The research additionally exhibits a excessive depth of collaboration of the CNR inside worldwide analysis networks. A key discovering of this research is to indicate, for the primary time, that though unsure reforms and reductions of public funds, scientific productiveness is rising. The administration and analysis coverage implications of this research may be generalized to help an environment friendly organizational and managerial conduct, and better scientific productiveness of public analysis institutes in contexts of lowered public funding and market turbulence.

fiddle: a tool to combat publication bias by getting research out of the file drawer and into the scientific community

fiddle: a tool to combat publication bias by getting research out of the file drawer and into the scientific community

Statistically important findings usually tend to be revealed than non-significant or null findings, leaving scientists and healthcare personnel to make choices based mostly on distorted scientific proof. Repeatedly increasing ´file drawers’ of unpublished information from well-designed experiments waste assets creates issues for researchers, the scientific group and the general public. There may be restricted consciousness of the unfavourable impression that publication bias and selective reporting have on the scientific literature.

Various publication codecs have lately been launched that make it simpler to publish analysis that’s tough to publish in conventional peer reviewed journals. These embody micropublications, information repositories, information journals, preprints, publishing platforms, and journals specializing in null or impartial outcomes. Whereas these different codecs have the potential to scale back publication bias, many scientists are unaware that these codecs exist and do not know how one can use them.

Our open supply file drawer information liberation effort (fiddle) software is a match-making Shiny app designed to assist biomedical researchers to establish essentially the most applicable publication format for his or her information. Customers can seek for a publication format that meets their wants, evaluate and distinction totally different publication codecs, and discover hyperlinks to publishing platforms. This software will help scientists in getting in any other case inaccessible, hidden information out of the file drawer into the scientific group and literature.

Pitfalls in scientific analysis: vital appraisal of articles revealed in one of many worldwide journals in Egypt

To establish and report flaws of Web-published articles within the Journal of the Egyptian Nationwide Most cancers Institute (JENCI), Cairo College, by means of a retrospective documentary research on articles revealed through the interval from 2011 to 2016. All sections have been reviewed in opposition to a collective guidelines. Articles have been grouped by publication yr into 2 intervals: early (from 2011 to 2013) and up to date (from 2014 to 2016) to establish adjustments in research traits over time. The research included 139 unique articles. Half of the titles represented purpose and 9.4% represented research design.
Abstracts have been concise, clear, with structured writing format in 98.6%, 93.5%, and 35.3%, respectively. Most introductions included the research purpose, whereas 41% had a rationale. Examine timing was reported in 59.0%, whereas the research design was reported in 25.9%. Inclusion and exclusion standards have been clearly reported in 43.1% and 40.1%, respectively. Statistical strategies have been talked about in 80.6%, full in 30.4%, and applicable in 85.7%. We briefly spotlight important particulars that ought to be included to make sure reporting high quality, which is able to enable others to make use of and profit from analysis revealed in these new codecs.
4 research reported pattern measurement estimation. Solely 52.5% and 58.3% of outcomes have been exhaustive and reply the analysis query, respectively. Incorrect statistical calculations occurred in 41.0%, inappropriate statistical checks or descriptive parameter choice in 26.6%, whereas inappropriate take a look at software occurred in 49.1%. About 60% of discussions didn’t fully cowl outcomes, 31.7% totally justified the findings, 56.1% adopted a logical circulate, and 36.7% had contradiction inside the textual content. Conclusions have been principally linked to purpose, imprecise, and extrapolating past outcomes.
On evaluating each intervals, solely a major much less misuse of statistical phrases, extra reporting battle of curiosity, extra lacking references for cited texts within the current interval, and extra participation of NCI over different institutes within the early interval have been discovered. Articles revealed in JENCI (from 2011 to 2016) had many methodological and reporting defects and a few factors of energy. Utilizing the collective guidelines developed by this research, steady coaching of researchers, involving epidemiologists all through the entire analysis course of, and making use of strict journal reporting and publication guidelines ought to be inspired.
fiddle: a tool to combat publication bias by getting research out of the file drawer and into the scientific community

A complete bibliometrics of ‘walkability’ analysis panorama: visualization of the scientific progress and future prospects

This research quantitatively investigated the scientific progress of walkability analysis panorama and its future prospects utilizing bibliometric indicators to spotlight the analysis hotspots. The outcomes accentuated multifaceted nature of walkability analysis panorama with a robust affiliation in direction of public well being disciplines. Key phrase co-occurrence evaluation emphasised that majority of the walkability research centred on the interactions between strolling and different three predominant elements resembling constructed atmosphere attributes, transportation and weight problems.

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Primarily based on the recognized analysis hotspots, a quick state-of-the-art overview of walkability research was offered. Future prospects based mostly on the unexplored analysis gaps inside the hotspots have been additionally mentioned. Excessive correlation (r = 0.99, p < 0.05) between annual publications and quotation counts demonstrated the importance of walkability research to the modern scientific group. Being one of many complete research to guage the historic trajectory of walkability analysis panorama, the findings have been anticipated to speed up a complete understanding of the walkability analysis area that can help future analysis route.