NIH Funding, Research Productivity, and Scientific Impact: a 20-Year Study

NIH Funding, Research Productivity, and Scientific Impact: a 20-Year Study

The paper addresses the problems of admissibility of human embryo analysis and the authorized safety to be acknowledged, in gentle of the rising significance that scientific analysis has been gaining within the medical and biomedical fields of embryonic stem cells for therapeutic functions. As for human embryo experimentation, notably on cryopreserved supernumerary embryos, European laws varies, for the reason that European Court docket has granted member States a large margin of appreciation.

Some nations, together with Italy, have strict laws defending embryos from the fertilisation stage, whereas others have taken permissive approaches, permitting experimentation till 14 days after fertilisation. Science, nevertheless, has proven that the 14-day restrict may be moved. The creator finds it mandatory to realize broad worldwide consensus and shared laws. Lawmakers, nevertheless, must stability respect for the precept of life, represented by the embryo, towards scientific wants, in an effort to devise sound laws safeguarding each apparently conflicting basic values.

The Analysis Challenge Grant (R01) is the oldest grant mechanism utilized by the Nationwide Institutes of Well being (NIH). Receiving an R01 award is usually taken as an indication of scientific success. We introduced normative information on a number of productiveness and impression metrics for a extra goal evaluation of funded grants’ scientific success.  All preliminary R01 grants awarded by NIH within the 12 months 2000 had been prospectively adopted and evaluated utilizing the numbers of publications and citations, in addition to the h-indices on the grant degree. We examined the variability, time traits, and relations amongst these metrics to raised perceive the funded tasks’ cumulative output and impression.

Introducing Key Components Relating to Entry to Private Information for Scientific Analysis within the Perspective of Growing Revolutionary Medicines

This text goals at opening discussions and selling future analysis about key components that must be taken under consideration when contemplating new methods to organise entry to non-public information for scientific analysis within the perspective of creating revolutionary medicines. It supplies an summary of those key components: the alternative ways of accessing information, the speculation of the important services, the Regulation on the Free Move of Non-personal Information, the Directive on Open Information and the re-use of public sector data, and the Basic Information Safety Regulation (GDPR) guidelines on accessing private information for scientific analysis.

Within the perspective of fostering analysis, selling revolutionary medicines, and having all of the uncooked information centralised in huge databases localised in Europe, we advise to additional examine the likelihood to search out acceptable and balanced options with full respect of basic rights, in addition to for personal life and information safety. These embrace utilizing open science platforms, pre-registering research, making certain reproducible analyses, utilizing high-powered research, making certain open entry to analysis supplies and merchandise, and conducting replication research.

Suicide analysis is vitally vital, yet-like psychology analysis extra broadly-faces methodological challenges. In recent times, researchers have raised considerations about customary practices in psychological analysis, considerations that apply to suicide analysis and lift questions on its robustness and validity. Within the current paper, we evaluate these considerations and the corresponding options put forth by the “open science” neighborhood.

We construct upon current guides, deal with particular obstacles confronted by suicide researchers, and supply a transparent set of beneficial practices for suicide researchers. Specifically, we contemplate challenges that suicide researchers could face in searching for to undertake “open science” practices (e.g., prioritizing massive samples) and recommend attainable methods that the sector could use in an effort to guarantee strong and clear analysis, regardless of these challenges.

NIH Funding, Research Productivity, and Scientific Impact: a 20-Year Study

Enhancing open and rigorous science: ten key future analysis alternatives associated to rigor, reproducibility, and transparency in scientific analysis

As a part of a coordinated effort to broaden analysis exercise round rigor, reproducibility, and transparency (RRT) throughout scientific disciplines, a crew of investigators on the Indiana College Faculty of Public Well being-Bloomington hosted a workshop in October 2019 with worldwide leaders to debate key alternatives for RRT analysis.

The workshop aimed to establish analysis priorities and alternatives associated to RRT.  Over two-days, workshop attendees gave displays and took part in three working teams: (1) Enhancing Training & Coaching in RRT, (2) Lowering Statistical Errors and Rising Analytic Transparency, and (3) Wanting Outward: Rising Truthfulness and Accuracy of Analysis Communications. Following small-group discussions, the working teams introduced their findings, and contributors mentioned the analysis alternatives recognized. The investigators compiled an inventory of analysis priorities, which had been circulated to all contributors for suggestions.

Scientific Pack for arium - EACH

WAT4290 EACH
EUR 379.35

Thermo Scientific SL1 Plus - EACH

75009600 EACH
EUR 6654.15

Thermo Scientific SL1R Plus - EACH

75009630 EACH
EUR 11371.05

Thermo Scientific SL4F Plus - EACH

75009951 EACH
EUR 14316.75

Thermo Scientific SL4RF Plus - EACH

75009953 EACH
EUR 17348.85

Thermo Scientific SL8 Centrifuge - EACH

75007221 EACH
EUR 4064.85

Incubator Genie Scientific Industries - EACH

MIX5090 EACH
EUR 6442.2

Heathrow Scientific PCR Cooler 96 Well Pink - PK2

RAC3122 PK2
EUR 228.15

Heathrow Scientific PCR Cooler 96 Well Blue - PK2

RAC3124 PK2
EUR 228.15

Thermo Scientific Centrifuge Multifuge X1 Pro - EACH

75009710 EACH
EUR 8577.9

Thermo Scientific Centrifuge Multifuge X1R Pro - EACH

75009750 EACH
EUR 13644.45

Heathrow Scientific PCR Cooler 96 Well Assorted - PK2

RAC3126 PK2
EUR 228.15

Thermo Scientific mySPIN 6 Mini Centrifuge 12V Adapter - EACH

75004087 EACH
EUR 73.04

Thermo Scientific Centrifuge Multifuge X1 Pro-MD IVD Version - EACH

75009210 EACH
EUR 8758.8

Thermo Scientific Centrifuge Multifuge X1R Pro-MD IVD Version - EACH

75009250 EACH
EUR 13811.85

Thermo Scientific mySPIN 6 Mini Centrifuge Portable Kit Complete - EACH

75004085 EACH
EUR 658.8

Thermo Scientific mySPIN 6 Mini Centrifuge Transport Box with Inserts - EACH

75004086 EACH
EUR 189

220V/50hz conversion for Powers Scientific Floor Incubators

M-CI-220V 1 UNIT
EUR 760
Description: 220V/50hz conversion for Powers Scientific Floor Incubators

Clipping tool repair for the Thermo Scientific Krios and Arctica ONLY

M-CEM-TFCT-RS 1 SERVICE
EUR 350
Description: Clipping tool repair for the Thermo Scientific Krios and Arctica ONLY

White Marker Pen - EACH

PCR1376 EACH
EUR 47.12

Direct Tube Marker - EACH

PCR1414 EACH
EUR 7917.75

Lab Marker Pen Blue - PK10

LAB2902 PK10
EUR 101.35

Lab Marker Pen Green - PK10

LAB2904 PK10
EUR 101.35

Nalgene Cryo Marker Set - PK4

CRY8332 PK4
EUR 36.45

Nalgene Cryo Marker Black - PK4

CRY8333 PK4
EUR 36.45

Tube Marker Ribbon White - EACH

PCR1416 EACH
EUR 207.9

Tube Marker Ribbon Black - EACH

PCR1418 EACH
EUR 207.9

Comb Prep 1 Marker 1.2mm thick

MS2012 EACH
EUR 52.47

Comb Prep 2 Marker 2.2mm thick

MS2022 EACH
EUR 52.47

Comb Prep 1 Marker 1.2mm thick

MS712 EACH
EUR 35.64

Comb Prep 4 Marker 2.2mm thick

MS742 EACH
EUR 35.64

Marker Pen Artline 70 Black - PK12

LAB3150 PK12
EUR 44.8

Blue/Red/Green proteins marker - 500 uL - EACH

DD523005 EACH
EUR 232.2

Marker Pen Artline 70 Yellow - PK12

LAB3158 PK12
EUR 45.09

SmartCheck™ Blue Protein Marker, 10 bands 9-180 kDA, 2x250ul

PR5010-BL 1 each
EUR 127.3

SmartCheck™ Blue Protein Marker, 11 bands 9-180 kDA, 2x250ul

PR5011-BL 1 each
EUR 131.6

Greiner Marker Pen FINE black - PK10

G840067 PK10
EUR 18.52

Comb Prep 1 Marker 1 1mm thick

MS1511 EACH
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Comb Prep 1 Marker 1 1.5mm thick

MS15115 EACH
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Comb Prep 2 Marker 2 1mm thick

MS1521 EACH
EUR 48.51

Comb Prep 2 Marker 2 1.5mm thick

MS15215 EACH
EUR 46.53

Comb Prep 4 Marker 2 1mm thick

MS1541 EACH
EUR 48.51

Comb Prep 4 Marker 2 1.5mm thick

MS15415 EACH
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Comb Prep 4 Marker 2 2mm thick

MS1542 EACH
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Comb Prep 1 Marker 1 1mm thick

MS2011 EACH
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Comb Prep 1 Marker 1 1.5mm thick

MS20115 EACH
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Comb Prep 2 Marker 2 1mm thick

MS2021 EACH
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Comb Prep 4 Marker 2 1mm thick

MS2041 EACH
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Comb Prep 4 Marker 2 1.5mm thick

MS20415 EACH
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Comb Prep 1 Marker 1 1mm thick

MS711 EACH
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Comb Prep 1 Marker 1 1.5mm thick

MS7115 EACH
EUR 33.66

Comb Prep 2 Marker 2 1mm thick

MS721 EACH
EUR 35.64

Comb Prep 2 Marker 2 1.5mm thick

MS7215 EACH
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Comb Prep 2 Marker 2 2mm thick

MS722 EACH
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Comb Prep 4 Marker 2 1mm thick

MS741 EACH
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Comb Prep 4 Marker 2 1.5mm thick

MS7415 EACH
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Comb 1 Prep 1 Marker 1mm thick

VS2011 EACH
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Comb 1 Prep 1 Marker 1.5mm thick

VS20115 EACH
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Comb 1 Prep 1 Marker 2mm thick

VS2012 EACH
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Comb 1 Prep 1 Marker 1mm thick

VS3011 EACH
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Comb 1 Prep 1 Marker 1.5mm thick

VS30115 EACH
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Comb Prep 1 Marker 1 0.75mm thick

MS151075 EACH
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Comb Prep 2 Marker 2 0.75mm thick

MS152075 EACH
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Comb Prep 4 Marker 2 0.75mm thick

MS154075 EACH
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Comb Prep 1 Marker 1 0.75mm thick

MS201075 EACH
EUR 50.49

Comb Prep 4 Marker 2 0.75mm thick

MS204075 EACH
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Comb Prep 1 Marker 1 0.75mm thick

MS71075 EACH
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Comb Prep 2 Marker 2 0.75mm thick

MS72075 EACH
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Comb Prep 4 Marker 2 0.75mm thick

MS74075 EACH
EUR 33.66

Comb 1 Prep 1 Marker 0.75mm thick

VS201075 EACH
EUR 46.53

Sharpie Black Marker Pens Black - PK12

LAB2150 PK12
EUR 64.26

Comb Prep 1 Marker 1.2mm thick - EACH

MS1512 EACH
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Comb Prep 2 Marker 2.2mm thick - EACH

MS1522 EACH
EUR 66.15

Comb Prep 4 Marker 2.2mm thick - EACH

MS2042 EACH
EUR 71.55

Marker Pen Frost Resistant Black - PK12

LAB3190 PK12
EUR 54.35

Tube marker Ribbon Metallic Blue - EACH

PCR1402 EACH
EUR 206.55

Edding Lab Marker 1mm Tip Black - PK10

E8014 PK10
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SmartCheck™ Tri-color Protein Marker, 10 bands 9-180 kDA, 2x250ul

PR5010-TC 1 each
EUR 148.63

Comb Prep 1 Marker 1 1mm thick - EACH

MS1011 EACH
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Comb Prep 1 Marker 1 1.5mm thick - EACH

MS10115 EACH
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Comb Prep 2 Marker 2 1mm thick - EACH

MS1021 EACH
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Comb Prep 2 Marker 2 1.5mm thick - EACH

MS10215 EACH
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Comb Prep 2 Marker 2 2mm thick - EACH

MS1022 EACH
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Comb Prep 4 Marker 2 1mm thick - EACH

MS1041 EACH
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Comb Prep 4 Marker 2 1.5mm thick - EACH

MS10415 EACH
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Comb Prep 4 Marker 2 2mm thick - EACH

MS1042 EACH
EUR 56.7

Comb 1 Prep 1 Marker 1mm thick - EACH

VS1011 EACH
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Comb 1 Prep 1 Marker 1.5mm thick - EACH

VS10115 EACH
EUR 44.55

Comb 1 Prep 1 Marker 2mm thick - EACH

VS1012 EACH
EUR 48.6

Comb Prep 1 Marker 1 0.75mm thick - EACH

MS101075 EACH
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Comb Prep 2 Marker 2 0.75mm thick - EACH

MS102075 EACH
EUR 54

Comb Prep 4 Marker 2 0.75mm thick - EACH

MS104075 EACH
EUR 54

Comb 1 Prep 1 Marker 0.75mm thick - EACH

VS101075 EACH
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Scienceware drying tubes

Z118559-12EA PK12
EUR 37.56

Scienceware drying tubes

Z118567-12EA PK12
EUR 48.96

LMW SDS Marker Kit 10 vials of 575ug - EACH

17044601 EACH
EUR 409.05

HMW SDS Marker Kit 10 vials of 175ug - EACH

17061501 EACH
EUR 437.4

Edding Lab Fine Marker 0.75mm Tip Black - PK10

E8015F PK10
EUR 54

Scienceware bench liners - EACH

L2271-1EA EACH
EUR 86.94

Mettler Inlab Science Probe - EACH

PHE0320 EACH
EUR 367.2

Scienceware drying tubes - PK12

Z118540-12EA PK12
EUR 39.69

HMW Native Marker Kit 10 vials of 250ug - EACH

17044501 EACH
EUR 409.05

Lab Marker Fine Tip Pen Ipa Ink Resistant - PK10

PEN40 PK10
EUR 133.65

Scienceware vacuum desiccator

Z119016-1EA EACH
EUR 160.32

SmartCheck™ Tri-color Extended Range Protein Marker, 12 bands 9-245 kDA, 2x250ul

PR5012-TC 1 each
EUR 170.47

SCIENCEWARE(R) LAB COMPANION(TM) CABINE - EACH

BAF424004031-1EA EACH
EUR 2902.5

Scienceware vacuum desiccator - EACH

Z119008-1EA EACH
EUR 107.06

Scienceware pipette support rack - EACH

Z136107-1EA EACH
EUR 53.33

Scienceware polypropylene trays

Z177822-1EA EACH
EUR 64.43

SmartCheck™ Tri-color Extended Range Plus Protein Marker, 13 bands 9-245 kDA, 2x250ul

PR5013-TC 1 each
EUR 183.55

Scienceware biohazard disposal bags

B8151-100EA PK100
EUR 25.2

Scienceware POXYGRID test-tube rack - EACH

Z135828-1EA EACH
EUR 76.95

Scienceware polypropylene trays - EACH

Z177814-1EA EACH
EUR 30.78

Scienceware lab-aire ii non-electrical d

Z673471-1EA EACH
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Scienceware(R) gel incubating trayWxL 9.0mm (3.5 in.)x9.0mm (3.5 in.) - PK5

BAF451000001-5EA PK5
EUR 66.98

Scienceware heavy-duty test-tube rack - EACH

Z178128-1EA EACH
EUR 69.26

Scienceware® Break-Safe Ampule Opener - EACH

Z693847-1EA EACH
EUR 89.1

Scienceware biohazard disposal bags - PK200

B8276-200EA PK200
EUR 624.24

Scienceware biohazard disposal bags - PK100

B4408-100EA PK100
EUR 203.85

Scienceware piezoelectric lighter - EACH

Z115231-1EA EACH
EUR 65.88

Scienceware lab-aire ii non-electrical d - EACH

Z673463-1EA EACH
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Lab Wet and Dry Marker Pen Solvent Resistant Black - PK10

LAB2900 PK10
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Scienceware Coplin staining jar with screw cap - PK12

S5641-12EA PK12
EUR 191.7

Scienceware cloning cylinders polystyrene

C7983-50EA PK50
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MSMIDI 96 Comb 8 sample MC 1mm thick. one marker lane. - EACH

MSMIDI9681 EACH
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MSMIDI 96 Comb 8 sample MC 1.5mm thick. one marker lane. - EACH

MSMIDI96815 EACH
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Scienceware(R) engraving tool battery poweredL 17.8 cm (7 in.) - EACH

BAF441500005-1EA EACH
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Scienceware polypropylene Buchner funnel - EACH

Z178136-1EA EACH
EUR 30.23

Scienceware cloning cylinders polystyrene - PK50

C3858-50EA PK50
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Scienceware centrifuge tube rack epoxy-coated steel

R8509-1EA EACH
EUR 72.38

Scienceware centrifuge tube rack epoxy-coated steel

R8634-1EA EACH
EUR 52.47

Scienceware filter paper discs for Buchner funnels - PK100

Z177601-100EA PK100
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Scienceware protective lab-labeling system tape - EACH

Z115509-1EA EACH
EUR 64.53

Scienceware centrifuge tube rack epoxy-coated steel - EACH

R8384-1EA EACH
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Scienceware(R) POXYGRID(R) test-tube rackfor tubes 18 - 20mm no. of holes 60 - EACH

BAF187630160-1EA EACH
EUR 77.63

Scienceware(R) vacuum aspirator bottle with trapcapacity 1.0 gal - EACH

BAF199170002-1EA EACH
EUR 340.2

Scienceware(R) Lab Companion round vacuum desiccatorvolume 20 L clear polycarbonate pack of 1 ea - EACH

BAF424002221-1EA EACH
EUR 525.15

Scienceware(R) Lab Companion cabinet vacuum desiccatorvolume 23 L clear polycarbonate pkg of 1 ea - EACH

BAF424004021-1EA EACH
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Protein Marker Ultra Marker

E36G623 500 μl/100 loads
EUR 100

0.5ML Insite Markers - 0.5ML

NAT1276 0.5ML
EUR 297

Protein Marker

TTOPP-1601 20Lanes
EUR 101.28

Markers Black lab broad point for glass plastic and metal - PK12

63110010 PK12
EUR 83.7

HighRange Rainbow Molecular Weight Markers 250ul

RPN800E EACH
EUR 269.04

Amersham ECL DualVue Western Blotting Markers - EACH

RPN810 EACH
EUR 298.35

Amersham ECL Plex Fluorescent Rainbow Markers 120 ul - EACH

RPN850E EACH
EUR 124.2

LowRange Rainbow Molecular Weight Markers 250ul - EACH

RPN755E EACH
EUR 298.35

Members recognized the next precedence analysis questions: (1) Can RRT-focused statistics and mathematical modeling programs enhance statistics apply?; (2) Can specialised coaching in scientific writing enhance transparency?; (3) Does modality (e.g. nose to nose, on-line) have an effect on the efficacy RRT-related schooling?; (4) How can automated packages assist establish errors extra effectively?; 

What’s the prevalence and impression of errors in scientific publications (e.g., analytic inconsistencies, statistical errors, and different goal errors)?; (6) Do error prevention workflows cut back errors?; (7) How can we encourage post-publication error correction?; (8) How does ‘spin’ in analysis communication have an effect on stakeholder understanding and use of analysis proof?; (9) Do instruments to assist writing analysis studies enhance comprehensiveness and readability of analysis studies?; and (10) Is it attainable to inculcate scientific values and norms associated to truthful, rigorous, correct, and complete scientific reporting? Members recognized vital and comparatively unexplored questions associated to bettering RRT. This record could also be helpful to the scientific neighborhood and investigators searching for to advance meta-science (i.e. analysis on analysis).